Volume 14, No 14, December 2001

Questionable Pills
ByShahida Nisar

Be suspicious of dramatic weight-loss claims and pay even closer attention to the risks.
Temporarily entering the world of insomniacs one night, I picked up the TV remote to see what those restless souls watched while most of us are off in dreamland. Between reruns of comedies and endless weather forecasts, I was captivated by a commercial hawking supplements to "boost your metabolism and burn away the fat." Astonished by the claims, I logged on to the Internet and began investigating.

It turns out such supplements are as prolific as an insomniac’s sheep, with name like Liquid Clenbutrx, MD6, Metabolic Complete, Hydroxycut, Xenadrine RFA-1 and Stacker 3, to mention just a few. Some are available as liquids; others come in large, multi coloured pills. But generally they promise the same thing: by speeding up your metabolism, they can reduce your fat, a claim I could not substantiate even after hours online and calls to several manufacturers.

These supplements are supposed to work by increasing thermogenesis, that is, by converting more of the food you eat into heat before it can b e stored as fat. Being able to do this safely would, of course, be a welcome way to avoid the buildup of fat and keep off extra pounds, but there are few if any studies in the scientific literature showing that these products can do this effectively or safely. Even so, thanks to a marketing blitz, the supplements have become a multibillion dollar industry.

What’s distressing is that although they don’t work, they are not risk free. Most contain the controversial ingredient ephedra (a Chinese herb also known as mahuang) or ephedrine. The U.S. Food and Drug Administration has received reports of 80 deaths and about, 1,400 instances of adverse effects that may be associated with the use for the herb, and has issued strong warnings about the use of ephedrine-containing products. Their potential side effects include heart attack, stroke, seizures, psychosis and death. The products are even packaged with a long list of user warnings.

More dangerous still are variants containing combos of ephedrine, caffeine, pseudo-ephedrine and the more potent norephedrine. While the last two ingredients are used in common over-the-counter cold remedies, they can produce dangerous side effects similar to those of the banned drug methamphetamine.

If you want to increase your metabolism, there is really only one safe and reliable way to do it. Increase your physical activity, whether it’s walking briskly, lifting weights or playing a vigorous game of tennis. Not only will the exertion help you shed some pounds, but it’s also more beneficial to the heat and skeletal muscles. Keep your money in your pocket. There are no shortcut pills to a leaner body.

Shady Deals
By J.K. Tukra

Could your sunglasses be damaging your eyes? How to shop for the best kind of protection?
Whether you’re headed for the beach or the lake, or whether you just plan to hand out in the garden this summer, you probably already know how to protect your skin against the sun’s harmful rays. Just slip on a shirt, slap on a hat and slop on plenty of sunscreen, preferably with an SPF rating of at least 30. But are you doing everything you can to safeguard your eyes? Don’t be so sure the answer is yes, even if you sport the latest in designer sunglasses.

Many shades on the market don’t fully block the two main types of ultraviolet radiation (A and B) that have been linked to everything from wrinkles to sunburn to skin cancer. Ophthalmologists are increasingly convinced that prolonged exposure can lead to a host of vision problems as well.

Sometimes the trouble shows up right away. Water skiers, or snow skiers for that matter, can develop a type of temporary blindness, called photokeratitis, that occurs when reflected sunlight actually burns the cornea, the clear covering over the eye. Other conditions may be triggered after years of exposure. Studies have linked UV radiation to an increased risk of cataracts, in which the lenses of they eyes become cloudy, as well as to macular degeneration, in which the cells in the central part of the retina slowly die.

The right pair of sunglasses doesn’t have to burn through your bank account. Whether you’re eyeing a real bargain or an expensive pair of Persols, make sure there’s an official decal indicating that the lenses absorb 99% to 100% of the UVA and UVB rays. What you shouldn’t accept, however, is any nonspecific wording such as "UV block" or "maximal UV protection." Specific numbers should always be attached.

Without the right decal, deeper tints can actually make things much worse. It’s normal for our eyes to widen and let in more light when we wear dark glasses. Unless the lenses are already designed to absorb ultraviolet light, the risk damaging the eyes only grows.

For a little extra margin of safety, choose lenses that are "polarized." This cuts down on glare by deflecting the sunlight that bounces off such smooth surfaces as sand, water and pavement.

The style for the frames can be as important as the lenses, and the trick here is to protect your eyes not only from direct light but also from the light that strikes at different angles, whether from above or the sides. Wraparound frames that fit snugly against your face are most effective at closing off these open spaces. Even those large Jackie O frames that have come back into style are a good choice because they cover all of the eye socket and surrounding areas.

Don’t forget the kids. Chances are they are outdoors more than you. Whatever you do, don’t toss your sunglasses once summer is over. Ultraviolet radiation doesn’t disappear on cloudy days or in winter. Preserving your vision is a year-round job.


Stents & Clots
By R.A Chan

Clotting in the wake of a procedure to widen clogged blood vessels may be three times more common than doctors previously estimated, a new study says. Researchers say the risk of potentially life-threatening thrombosis after the placement of a stent to improve blood flow is as high as 3.5 per 100 operations. Earlier estimates put that rate at about 1 percent to 1.5 percent.

Stents, wire mesh sleeves that help restore normal blood flow in blocked vessels, are becoming increasingly common in the United States. Nearly 500,000 are installed each year, usually after angioplasty to open a narrowed channel. But the devices are prone to two serious complications. One is restenosis, when the vessel narrows and again crimps blood flow. The other is the formation of blood clots that can break off and lead to heart attacks. The clots generally occur within two weeks to a month after the stent procedure and are thought to be a direct result of trauma to the vessel lining when doctors install the device.

Dr. Thaddeus Tolleson, leader of the Duke University research team, says prior estimates of stent-related clotting are based on studies that excluded patients with acute coronary syndrome, a condition marked by critically impaired blood flow to the heart muscle that produces serious chest pain and can even lead to a small heart attack. Yet the condition is relatively common and accounts for as much as 40 percent to 60 percent of the caseload for the average cardiologist.

So the researchers looked at data from two large trials that included subjects with acute coronary syndrome. Both trials compared sibrafiban, the so-called "super aspirin," with regular aspirin to prevent recurrent heart attacks.

Of the nearly 16,000 patients in the two studies, 4,641 underwent angioplasty followed by the placement of a stent. They were also given an anti-platelet drug to reduce the risk of clotting. In the first trial, 2.1 percent of patients suffered clots at the stent site. The number was 4.7 percent in the second trial. Diabetics, women, the elderly, those who've suffered at least one heart attack and those who already had angioplasty were more at risk of clots. Patients with more than one of these risk factors had an even greater chance of clotting. The findings shouldn't be interpreted as a reason to discourage stenting. That should definitely not be the take-home message because there's not an alternative that's better. The risk of clotting may be higher than previously believed. "the chances are still 97 percent that you'd fly through [a stent installation] without any problems. However, the researchers say the results should encourage cardiologists to look for ways to drive down the likelihood of stent-related clots, especially in patients with one or more risk factors for the complication. Such work already is well under way, as doctors now commonly pre-treat stent patients with anti-platelet drugs and stents that are coated with clot-busting compounds. Another view is that this might be due to differences in anti-platelet therapy from what's now the standard of care.

But if the work does hold up, it might make cardiologists think twice about placing stents in patients at high risk of clotting, since the complication is extremely serious. You have to reopen the artery immediately, which is a somewhat more dangerous procedure than the initial angioplasty.

 

 

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